West Midlands Railway (WMR) has issued a "do not travel" warning for Friday amid concerns over Storm Eunice
There will be a "significantly reduced" WMR service on Friday, but the operator says pre-booked tickets for the date are valid on Thursday and Saturday.
Storm Eunice is forecast to bring strong winds to the region, just two days after disruption by Storm Dudley.
Some West Midlands schools have decided to close on Friday as precautions are taken across the area.
It comes as The Met Office issued an amber weather warning locally, with a rare red one issued for the South West.
About 10 flood alerts are in place around the West Midlands. Flood barriers have already gone up in Bewdley and Shrewsbury, with the River Severn expected to peak on Saturday.
On Wednesday, Storm Dudley damaged the canopy above platforms at Wolverhampton railway station, causing delays and cancellations.
WMR said while services had resumed, the focus was now on Storm Eunice, leading to Friday's service reduction and complete service suspension on some routes.